Endocrine Abstracts

Multiple endocrine neoplasia type2 (MEN 2) (OMIM 171400) is an autosomal dominant inherited cancer syndrome caused by activating mutations in the RET proto-oncogene. MEN 2 is classified into three subtypes: MEN 2A, MEN 2B and familial medullary thyroid carcinoma(FMTC). MEN 2B accounts for 5–10% of MEN2 cases. More than 95% of MEN 2B patients carry M918T mutation of RET, and 2–3% harbor A883F mutation. There has been three reports of cases with MEN 2B phenotype caused...